The role of CD8+ T-cell replicative senescence in human aging.

  title={The role of CD8+ T-cell replicative senescence in human aging.},
  author={Rita B. Effros and Mirabelle D Dagarag and Carolyn Spaulding and Janice Man},
  journal={Immunological reviews},
The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. CD8(+) T cells that undergo extensive rounds of antigen-driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell-cycle arrest and a critically short telomere length. Cultures of senescent CD8(+) T cells… CONTINUE READING
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