The role of CD40 in peripheral T cell tolerance and immunity

  title={The role of CD40 in peripheral T cell tolerance and immunity},
  author={Linda Diehl and Annemieke Th. den Boer and E.I.H. van der Voort and C.J.M. Melief and Rienk Offringa and R Toes},
  journal={Journal of Molecular Medicine},
CD40 and CD40 ligand (CD40L) have been implicated as important molecules for the transformation of nonactivated antigen-presenting cells (APC) into cells that are potent inducers of cytotoxic T lymphocyte (CTL) immunity. The onset of a successful immune response lies within the control of the CD4+ T helper cells which, after specific antigen recognition, can up-regulate CD40L and subsequently activate APC through CD40 signaling. Triggering of CD40 with antibodies in vivo can replace the need… CONTINUE READING


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