The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection.

@article{Huffnagle1994TheRO,
  title={The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection.},
  author={Gary B Huffnagle and Mary Lipscomb and Julie A. Lovchik and Kathleen A. Hoag and Nancy E. Street},
  journal={Journal of leukocyte biology},
  year={1994},
  volume={55 1},
  pages={35-42}
}
Moderately virulent strains of Cryptococcus neoformans, inoculated via the trachea, cause a pulmonary infection in BALB/c mice that was gradually resolved by T lymphocyte-dependent mechanisms. The current studies, using monoclonal antibodies to deplete T cell subsets, demonstrated that CD4+ and CD8+ T cells combined to mediate a prominent pulmonary inflammatory infiltrate that included lymphocytes, macrophages, neutrophils, and eosinophils. The inflammatory response peaked 2 weeks after… CONTINUE READING

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