The role of CD4+ T-cells in the development of MS.

  title={The role of CD4+ T-cells in the development of MS.},
  author={Sylvia R Delgado and William A. Sheremata},
  journal={Neurological research},
  volume={28 3},
OBJECTIVE Multiple sclerosis (MS) is a chronic, progressive central nervous system (CNS) disease with unknown cause. Considerable evidence supports an autoimmune origin with an important role for cellular immune responses in its pathogenesis. METHODS We have reviewed the current literature dealing with lymphocyte responses and their interactions as it relates to MS and present supporting evidence from animal models. RESULTS Issues regarding CD4+ T-cell subpopulations, their functional… CONTINUE READING

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