The role of CD36 receptor in the pathogenesis of atherosclerosis.

  title={The role of CD36 receptor in the pathogenesis of atherosclerosis.},
  author={B. Choromanska and P. Myśliwiec and Katarzyna Choromańska and J. Dadan and A. Chabowski},
  journal={Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  volume={26 4},
  • B. Choromanska, P. Myśliwiec, +2 authors A. Chabowski
  • Published 2017
  • Medicine
  • Advances in clinical and experimental medicine : official organ Wroclaw Medical University
  • Atherosclerosis is a progressive, chronic inflammation in artery walls. Oxidized low density lipoproteins (ox-LDL) play an important role in atherosclerotic plaque formation. ox-LDL are taken up by macrophages mainly through scavenger receptors, among which CD36 is considered to be the most important. Animal studies have shown that crossing atherogenic mice with a strain lacking the expression of CD36 prevented the development of atherosclerosis despite a diet rich in saturated LCFA. In humans… CONTINUE READING
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