The role of CD 38 expression on NAD levels and cell physiology in a leukaemia model

@inproceedings{AlAbady2014TheRO,
  title={The role of CD 38 expression on NAD levels and cell physiology in a leukaemia model},
  author={Zainab Nejim Al-Abady},
  year={2014}
}
CD38 is a transmembrane glycoprotein with both ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities; it is also known as a cell surface receptor. CD38 utilizes NAD(P) as a substrate to produce the second messengers, Nicotinic acid adenine dinucleotide phosphate (NAADP) and Cyclic adenosine diphosphate ribose (cADPR). CD38 has been implicated in several diseases. For instance, in chronic lymphocytic leukemia (CLL), it is known as a poor prognostic marker and as a disease modifier. Also… CONTINUE READING

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