The role of CCL12 in the recruitment of fibrocytes and lung fibrosis.

  title={The role of CCL12 in the recruitment of fibrocytes and lung fibrosis.},
  author={Bethany B Moore and Lynne Murray and Anuk M. Das and Carol A. Wilke and Amy B Herrygers and Galen B. Toews},
  journal={American journal of respiratory cell and molecular biology},
  volume={35 2},
We have previously shown that mice that are genetically deficient in the CCR2 gene (CCR2-/- mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis. Protection from fibrosis correlated with impaired recruitment of fibrocytes (bone marrow-derived cells, which share both leukocyte and mesenchymal markers). There are three ligands for CCR2 in the mouse: CCL2, CCL7, and CCL12. CCL2 and CCL12 are both elevated in the lung after FITC injury, but with different kinetics. CCL2… CONTINUE READING
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