The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice.

@article{Schilling2009TheRO,
  title={The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice.},
  author={Matthias Schilling and Jan-Kolja Strecker and E. Bernd Ringelstein and Wolf R{\"u}diger Sch{\"a}bitz and Reinhard Kiefer},
  journal={Brain research},
  year={2009},
  volume={1289},
  pages={79-84}
}
The chemokine receptor 2 (CCR2) is involved in inflammatory reactions following cerebral ischemia. Monocyte chemoattractant protein-1 (MCP-1) binds with high affinity to CCR2. MCP-1 is necessary for recruiting blood-borne cells to the injury site whereas it does not affect microglia activation and migration. MCP-1-deficient mice develop smaller infarcts and show a better functional outcome. CCR2-deficient mice also develop smaller infarcts and have a reduced expression of inflammatory cytokines… CONTINUE READING

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