The role of C4d deposition in the diagnosis of antibody-mediated rejection after lung transplantation.

@article{Aguilar2018TheRO,
  title={The role of C4d deposition in the diagnosis of antibody-mediated rejection after lung transplantation.},
  author={Patrick R. Aguilar and Danielle Carpenter and Jon H. Ritter and Roger D. Yusen and ClaudiaM. Witt and Derek E. Byers and Thalachallour Mohanakumar and Daniel Kreisel and Elbert P. Trulock and R R Hachem Hachem},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2018},
  volume={18 4},
  pages={
          936-944
        }
}
Antibody-mediated rejection (AMR) is an increasingly recognized form of lung rejection. C4d deposition has been an inconsistent finding in previous reports and its role in the diagnosis has been controversial. We conducted a retrospective single-center study to characterize cases of C4d-negative probable AMR and to compare these to cases of definite (C4d-positive) AMR. We identified 73 cases of AMR: 28 (38%) were C4d-positive and 45 (62%) were C4d-negative. The two groups had a similar clinical… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-4 OF 4 CITATIONS

Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR).

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019

Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Donor-specific anti-HLA antibodies with antibody-mediated rejection and long-term outcomes following heart transplantation.

  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2017

Proteasome Inhibitor Carfilzomib-Based Therapy for Antibody-Mediated Rejection of the Pulmonary Allograft: Use and Short-Term Findings.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017

Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016

Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.

  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2016

Plasma-Derived C1 Esterase Inhibitor for Acute Antibody-Mediated Rejection Following Kidney Transplantation: Results of a Randomized Double-Blind Placebo-Controlled Pilot Study.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016

Presentation and Outcomes of C4d-Negative Antibody-Mediated Rejection After Kidney Transplantation.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016