The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.

@article{PradhanSundd2014TheRO,
  title={The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.},
  author={Tirthadipa Pradhan-Sundd and Esther M Verheyen},
  journal={Developmental biology},
  year={2014},
  volume={392 1},
  pages={
          93-107
        }
}
Wingless (Wg) proteins are secreted-lipid-modified glycoproteins involved in tissue patterning and cell-fate specification. Wg secretion is regulated by a specialized mechanism involving a repertoire of proteins including Wntless (Wls). Here, we show that the Bro1-domain-containing protein Myopic (Mop) is indispensable for endosomal trafficking of Wg and Wls. Reductions in Mop leads to trapping of Wg and Wls in the early endosomes. Overexpression of the endosomal sorting protein Hepatocyte… CONTINUE READING
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