The role of BRCA1 in transcriptional regulation and cell cycle control

@article{Mullan2006TheRO,
  title={The role of BRCA1 in transcriptional regulation and cell cycle control},
  author={Paul Mullan and Jennifer E. Quinn and Denis Paul Harkin},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={5854-5863}
}
The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in relation to transcriptional regulation and in particular how this impacts upon cell cycle control. We will (i) describe the structure of BRCA1 and how it may contribute to its… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS