The role of BRCA mutation testing in determining breast cancer therapy

@article{Trainer2010TheRO,
  title={The role of BRCA mutation testing in determining breast cancer therapy},
  author={Alison H. Trainer and Craig R. Lewis and Kathy Tucker and Bettina Meiser and Michael Friedlander and Robyn Lynne Ward},
  journal={Nature Reviews Clinical Oncology},
  year={2010},
  volume={7},
  pages={708-717}
}
Landmark discoveries in the field of breast cancer research include the identification of germline BRCA mutations as a cause of hereditary disease, and the use of gene-expression profiling to identify distinct subtypes of breast cancer. These findings, coupled with the availability of rapid germline testing, make it possible to identify a BRCA mutation carrier contemporaneous with a diagnosis of breast cancer. For the first time, testing for a germline mutation that predisposes to cancer has… CONTINUE READING

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