The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis.

@article{Mano1996TheRO,
  title={The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis.},
  author={Mitsugu Ma{\'e}no and Paul Evan Mead and C. Kelley and Rosa Xu and Hsiange Fu Kung and Akira John Suzuki and Naoto Ueno and Leonard I. Zon},
  journal={Blood},
  year={1996},
  volume={88 6},
  pages={1965-72}
}
Vertebrate embryonic blood formation is regulated by factors that participate in dorsal-ventral patterning and mesoderm induction. The GATA-binding transcription factors are required for normal hematopoiesis and are expressed during gastrulation when ventral mesoderm (VM) is induced to form blood. Based on the recent demonstration that bone morphogenetic protein (BMP-4) is a potent ventralizing factor and inducer of hematopoietic tissue, we hypothesized that GATA-2 could be induced or activated… CONTINUE READING

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