The role of BETA2/NeuroD1 in the development of the nervous system

  title={The role of BETA2/NeuroD1 in the development of the nervous system},
  author={Jang-Hyeon Cho and M. Tsai},
  journal={Molecular Neurobiology},
  • Jang-Hyeon Cho, M. Tsai
  • Published 2004
  • Biology, Medicine
  • Molecular Neurobiology
  • BETA2/NeuroD1 is a member of the basic helix-loop-helix (bHLH) transcription factor family, which has been shown to play a major role in development of the nervous system and formation of the endocrine system. Gain-of-function studies have indicated that BETA2/NeuroD1 is important for the neurogenesis of Xenopus embryos and several neurogenic cell lines. Disruption of the gene encoding BETA2/NeuroD1 leads to severe abnormalities of the developing mouse central nervous system as well as the… CONTINUE READING
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