The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification.

@article{Ulici2009TheRO,
  title={The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification.},
  author={Veronica Ulici and Katie D. Hoenselaar and Hanga Agoston and David D. McErlain and Joseph U. Umoh and Subrata Chakrabarti and David W. Holdsworth and Frank M. Beier},
  journal={Bone},
  year={2009},
  volume={45 6},
  pages={1133-45}
}
Longitudinal bone growth is the result of endochondral bone formation which takes place in the growth plate. The rate of chondrocyte proliferation and hypertrophy, vascular invasion with the formation of primary ossification centers and cartilage replacement by bone tissue are all important processes required for normal growth. We have shown a role for the PI3K signaling pathway in chondrocyte hypertrophy and bone growth in tibia explant cultures. In this current study, we aimed to investigate… CONTINUE READING
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