The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors.

@article{Maekawa2010TheRO,
  title={The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors.},
  author={Toshio Maekawa and Wanzhu Jin and Shunsuke Ishii},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 3},
  pages={613-25}
}
ATF-2 is a member of the ATF/CREB family of transcription factors and is activated by stress-activated protein kinases, such as p38. To analyze the physiological role of ATF-2 family transcription factors, we have generated mice with mutations in Atf-2 and Cre-bpa, an Atf-2-related gene. The trans-heterozygotes of both mutants were lean and had reduced white adipose tissue (WAT). ATF-2 and CRE-BPa were required for bone morphogenetic protein 2 (BMP-2)-and p38-dependent induction of peroxisome… CONTINUE READING