The role of ATF‐2 in oncogenesis

@article{Vlahopoulos2008TheRO,
  title={The role of ATF‐2 in oncogenesis},
  author={Spiros A Vlahopoulos and Stella Logotheti and Dimitris Mikas and Athina Giarika and V. Gorgoulis and V. Zoumpourlis},
  journal={BioEssays},
  year={2008},
  volume={30}
}
  • Spiros A Vlahopoulos, Stella Logotheti, +3 authors V. Zoumpourlis
  • Published 2008
  • Medicine, Biology
  • BioEssays
  • Activating Transcription Factor‐2 is a sequence‐specific DNA‐binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c‐jun, which are involved in oncogenesis in various tissue types. ATF‐2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 117 REFERENCES
    Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • 1,481
    ATF‐2 contains a phosphorylation‐dependent transcriptional activation domain.
    • 499
    Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
    • 172
    • PDF