The role of ATF‐2 in oncogenesis

  title={The role of ATF‐2 in oncogenesis},
  author={Spiros A Vlahopoulos and Stella Logotheti and Dimitris Mikas and Athina Giarika and V. Gorgoulis and V. Zoumpourlis},
  • Spiros A Vlahopoulos, Stella Logotheti, +3 authors V. Zoumpourlis
  • Published 2008
  • Biology, Medicine
  • BioEssays
  • Activating Transcription Factor‐2 is a sequence‐specific DNA‐binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c‐jun, which are involved in oncogenesis in various tissue types. ATF‐2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for… CONTINUE READING
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