The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression

@article{Joy2016TheRO,
  title={The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression},
  author={Anna M. Joy and Manisha Kapoor and Joseph F. Georges and Lacy Butler and Yongchang Chang and Chaokun Li and Acacia Crouch and Ivan V. Smirnov and Mitsitoshi Nakada and James Hepler and Max Marty and Burt G. Feuerstein},
  journal={Journal of Neuro-Oncology},
  year={2016},
  volume={130},
  pages={43-52}
}
The growth factor receptor/PI3K/AKT pathway is an important drug target in many cancers including Glioblastoma. AKT, a key node in the pathway, has 3 isoforms, AKT1, AKT2 and AKT3. Here we investigate their role in GBM. We find each activated, ser473 phosphorylated isoform is present in some GBMs but expression patterns vary. There is a direct relationship between human GBM patient outcome and both AKT1 and AKT2 mRNA levels, but an inverse relationship with AKT3 mRNA. Furthermore, AKT3 mRNA… CONTINUE READING

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