The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience

@article{Angelides2014TheRO,
  title={The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience},
  author={Socrates Angelides and Manal El-Mashaleh and Marienne Anagnostou and G. Howe and David Spencer and Vijay Kumar and Nicholas Manolios},
  journal={Nuclear Medicine Communications},
  year={2014},
  volume={35},
  pages={655–665}
}
ObjectivesWe investigated the localization pattern of a novel imaging agent, 99mTc-labelled glucosamine (ECDG), in a variety of rheumatic conditions. Materials and methodsSixteen patients were recruited into the study, with either active rheumatoid arthritis or osteoarthritis. 99mTc-ECDG was prepared in-house and patients received 400 MBq intravenously; thereafter, static images were acquired 15 min, 2 h and 4 h later, using a dual-head Siemens e-cam. Images were interpreted by an experienced… 
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References

SHOWING 1-10 OF 27 REFERENCES
18F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3
TLDR
18F-FDG PET is a unique imaging technique for assessing the metabolic activity of synovitis and is correlated with MRI and US assessments of the pannus in RA, as well as with the classical serum parameter of inflammation, CRP, and the synovium-derived parameter, serum MMP-3.
Assessment of disease activity in rheumatoid arthritis with (18)F-FDG PET.
TLDR
F-FDG PET is a unique imaging technique that can assess the metabolic activity of synovitis and measure the disease activity in RA.
The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease
TLDR
It is shown that 18F-fluorodeoxyglucose positron emission tomography is highly effective in assessing the activity and the extent of large-vessel vasculitis and high sensitivity is achieved by scanning in the state of active inflammation.
F-18 FDG Whole-Body PET for the Assessment of Disease Activity in Patients With Rheumatoid Arthritis
TLDR
Visual assessment of FDG uptake shows a significant correlation with clinical evaluation of disease activity in patients with rheumatoid arthritis undergoing antiinflammatory treatment.
Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents.
TLDR
There are similarities between (99m)Tc ECDG uptake and (18)F FDG uptake in tumors, and study findings supported the potential use of ( 99m) Tc E CDG as a functional imaging agent.
[18F]fluorodeoxyglucose positron emission tomography is a useful tool to diagnose the early stage of Takayasu's arteritis and to evaluate the activity of the disease
Takayasu's arteritis (TA) is a rare disease that can be difficult to diagnose in its early stage. A young woman with a fever and neck pain was thought to have TA, although computed tomographic
New radiopharmaceuticals for imaging rheumatoid arthritis.
  • M. Chianelli, C. D’Alessandria, A. Signore
  • Medicine, Biology
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
  • 2006
TLDR
Currently available radiopharmaceuticals for imaging RA, with a special emphasis on recently developed agents and their use in therapy decision-making and follow-up are the focus of this article.
Fluorodeoxyglucose (FDG) uptake in pulmonary rheumatoid nodules
TLDR
Although rheumatoid pulmonary nodules are benign, confirmation to exclude coincidental malignancy is very important and FDG-PET is a noninvasive imaging technique, which acts as a metabolic biopsy and can help in avoiding morbidity and cost of invasive tissue sampling.
Complexities in the quantitative assessment of patients with rheumatic diseases in clinical trials and clinical care.
TLDR
Indices used in rheumatoid arthritis assess primarily disease activity, but separate indices have been developed to assess disease activity versus damage in patients with ankylosing spondylitis, systemic lupus erythematosus, and vasculitis.
Biomarkers in osteoarthritis.
TLDR
There is general agreement that development of DMOADs will be facilitated by advances in imaging and the validation of chemical biomarkers, which should be useful tools that will identify patients at risk for disease progression and predict responses to candidate structure-modifying drugs.
...
1
2
3
...