The role of 8-hydroxy-2'-deoxyguanosine in rifamycin-induced DNA damage.

  title={The role of 8-hydroxy-2'-deoxyguanosine in rifamycin-induced DNA damage.},
  author={Paulina Muniz and Vicente. Valls and C Perez-Broseta and Antonio Iradi and J V Climent and Maria R Oliva and Guillermo T S{\'a}ez},
  journal={Free radical biology & medicine},
  volume={18 4},
The effect of rifamycin SV on the formation of 8-hydroxy-2'-deoxyguanosine (8-0HdG) has been investigated in vitro and in vivo. Oxidative modification of 2'-deoxyguanosine has been measured as an indication of DNA damage using high-performance liquid chromatography with electrochemical detection. Rifamycin SV in the presence of copper(II) ions induces the formation of 8-0HdG in calf thymus DNA. The effect is enhanced by increasing the antibiotic concentration and inhibited by catalase and… CONTINUE READING


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