The role of 5-hydroxymethylcytosine in development, aging and age-related diseases

  title={The role of 5-hydroxymethylcytosine in development, aging and age-related diseases},
  author={V. Lopez and A. F. Fernandez and M. Fraga},
  journal={Ageing Research Reviews},
  • V. Lopez, A. F. Fernandez, M. Fraga
  • Published 2017
  • Biology, Medicine
  • Ageing Research Reviews
  • DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC), resulting from 5mC oxidation, is redefining our view of the epigenome, as multiple studies indicate that 5hmC is not simply an intermediate of DNA demethylation, but a genuine epigenetic mark that may play an important functional role in gene regulation. Currently, the availability of platforms that discriminates between the… CONTINUE READING
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