The role of 5-hydroxymethylcytosine in development, aging and age-related diseases

@article{Lopez2017TheRO,
  title={The role of 5-hydroxymethylcytosine in development, aging and age-related diseases},
  author={V. Lopez and A. F. Fernandez and M. Fraga},
  journal={Ageing Research Reviews},
  year={2017},
  volume={37},
  pages={28-38}
}
  • V. Lopez, A. F. Fernandez, M. Fraga
  • Published 2017
  • Biology, Medicine
  • Ageing Research Reviews
  • DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC), resulting from 5mC oxidation, is redefining our view of the epigenome, as multiple studies indicate that 5hmC is not simply an intermediate of DNA demethylation, but a genuine epigenetic mark that may play an important functional role in gene regulation. Currently, the availability of platforms that discriminates between the… CONTINUE READING
    29 Citations

    Topics from this paper

    New Insights into 5hmC DNA Modification: Generation, Distribution and Function
    • 65
    • PDF
    A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline
    • 8
    • PDF
    Advances in detection and quantification of methylcytosine and its derivatives.
    DNA methylation plays an important role in immune thrombocytopenia.

    References

    SHOWING 1-10 OF 192 REFERENCES
    Tet family proteins and 5-hydroxymethylcytosine in development and disease
    • 273
    • PDF
    Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
    • 576
    Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • 318
    • PDF
    Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation
    • 103
    • PDF
    Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
    • 4,104
    • PDF