The role of 5-hydroxymethylcytosine in development, aging and age-related diseases

@article{Lpez2017TheRO,
  title={The role of 5-hydroxymethylcytosine in development, aging and age-related diseases},
  author={Virginia L{\'o}pez and A. F. Fern{\'a}ndez and Mario F. Fraga},
  journal={Ageing Research Reviews},
  year={2017},
  volume={37},
  pages={28-38}
}
DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC), resulting from 5mC oxidation, is redefining our view of the epigenome, as multiple studies indicate that 5hmC is not simply an intermediate of DNA demethylation, but a genuine epigenetic mark that may play an important functional role in gene regulation. Currently, the availability of platforms that discriminates between the… 
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