The role of 5-HT3 receptors in periaqueductal gray-induced inhibition of nociceptive dorsal horn neurons in rats.


Electrical stimulation in the periaqueductal gray (PAG) can inhibit dorsal horn cell responses to both innocuous and noxious cutaneous stimuli. This inhibition is believed to be due to the release of serotonin (5-HT) into the dorsal horn of the spinal cord from descending axons of the nucleus raphe magnus and the adjacent reticular formation. It is still… (More)