The role of 5-HT2C receptors in affective disorders.

@article{Jenck1998TheRO,
  title={The role of 5-HT2C receptors in affective disorders.},
  author={François Jenck and Michael B{\"o}s and Jürgen Wichmann and Heinz Stadler and J. R. Martin and J. -L. Moreau},
  journal={Expert opinion on investigational drugs},
  year={1998},
  volume={7 10},
  pages={
          1587-99
        }
}
5-HT(2C) receptors are predominantly localised in the brain and their dysregulation may contribute to particular symptoms of anxiety and depression. The marked affinity of several clinically established psychotropic agents sites (e.g., tricyclic antidepressants, clozapine, fluoxetine) for 5-HT(2C) receptor has generated interest in the therapeutic potential of selective, high affinity 5-HT(2C) receptor ligands. Like the selective serotonin re-uptake inhibitor (SSRI) fluoxetine, high affinity… Expand
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