The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers

@article{Wingen2006TheRO,
  title={The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers},
  author={Marleen Wingen and Kim P. C. Kuypers and Johannes G Ramaekers},
  journal={Psychopharmacology},
  year={2006},
  volume={190},
  pages={391-400}
}
RationaleVarious studies have demonstrated a modulating role for serotonin in attention. Selective serotonin inhibitors have repeatedly been shown to impair performance in sustained attention tasks.ObjectivesTo assess the contribution of serotonin reuptake inhibition and specific blockade of the pre-synaptic 5-HT1a receptor and the 5-HT2a receptor to deficits in attention.Materials and methodsThe study was conducted according to a randomized, double-blind, placebo controlled, four-way crossover… Expand
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