The role of 5-HT1A receptors in learning and memory

  title={The role of 5-HT1A receptors in learning and memory},
  author={Sven Ove Ögren and Therese M. Eriksson and Elin Elvander-Tottie and Claudio D'Addario and Joanna C. Ekstr{\"o}m and Per Svenningsson and Björn Meister and J{\'a}n Kehr and Oliver Stiedl},
  journal={Behavioural Brain Research},

5-HT receptor-mediated modulation of glutamate transmission in the hippocampus and prefrontal cortex and its relation to cognition and depression

The work conducted in this thesis has contributed in understanding the interaction between serotonergic and glutamatergic systems in hippocampal and prefrontal cortex areas, providing novel insights upon mechanism of action of different classes of antidepressants reflected both at the behavioral and molecular level.

Role of Somatodendritic and Postsynaptic 5-HT1A Receptors on Learning and Memory Functions in Rats

This study suggests that 5-HT1A receptor could be used as a significant pharmacological target for the treatment of CNS diseases and may lead to new insights in understandings of learning and memory.

The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory

Findings highlight the differential role of these 5-HTRs in cognitive/emotional domains of behavior and indicate that tonic and phasic 5-HT release can exert different and potentially opposing effects on emotional memory, depending on the states of5-HT1ARs and 5- HT7Rs and their interaction.

Serotonin modulates outward potassium currents in mouse olfactory receptor neurons.

It is found that 5-HT decreased the magnitude of outward K(+) current in a dose-dependent manner and these inhibitory effects were markedly attenuated by the 5- HT(1A) receptor blocker WAY-100635 and the5-HT(1B) receptor antagonist GR55562, which suggested that 4-HT may play a role in the modulation of peripheral olfactory signals by regulating outward potassium currents.

Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior.

Recent findings and current perspectives on functional aspects of 5-HT(1A) auto- and heteroreceptors with particular regard to their involvement in altered anxiety and mood states are reviewed.

5-HT6 receptor memory and amnesia: behavioral pharmacology--learning and memory processes.

Do dorsal raphe 5-HT neurons encode “beneficialness”?




Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory.

Postsynaptic 5-HT(1A )receptors localized in the hippocampal formation have a negative influence on explicit memory function, which raises the possibility that the antagonistic effect of postsynaptic5-HT (1A) receptors in the hippocampus leads to improvement of human memory function.

Role of serotonin in memory impairment

Converging evidence suggests that the administration of 5-HT2A/2C or 5- HT4 receptor agonists or5-HT1A or 5HT3 and 5-ht1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand.

5-HT1A receptors and memory

A pharmacological analysis of serotonergic receptors: Effects of their activation of blockade in learning

  • A. MenesesE. Hong
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1997

Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism

The results suggest that serotonin suppresses NMDAR function through a mechanism dependent on microtubule/kinesin-based dendritic transport of NMDA receptors that is regulated by CaMKII and ERK signaling pathways.

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

3H-PAT seems to be a useful ligand for studying the biochemical and pharmacological characteristics of presynaptic autoreceptors in selected regions of rat brain.

5-Hydroxytryptamine(7) receptor activation decreases slow afterhyperpolarization amplitude in CA3 hippocampal pyramidal cells.

  • W. BaconS. Beck
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 2000
One of the receptors that mediates the decrease in sAHP amplitude in CA3 hippocampal pyramidal cells was concluded to be the 5-HT(7) receptor.