The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test

  title={The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test},
  author={Rudy Schreiber and Christophe Melon and Jean de Vry},
Abstract We evaluated whether the anxiolytic effects of selective serotonin reuptake inhibitors (SSRIs) in the rat ultrasonic vocalization (USV) test are preferentially mediated by (indirect) activation of 5-HT1A, 5-HT1B/1D, 5-HT2A, 5-HT3 or 5-HT4 receptors. The SSRIs, paroxetine (ED50 in mg/kg, IP: 6.9), citalopram (6.5), fluvoxamine (11.7) and fluoxetine (>30), dose dependently reduced shock-induced USV. The effects of paroxetine (3.0 mg/kg, IP) were not blocked by the selective 5-HT1A… 

Implication of 5-HT2 receptor subtypes in the mechanism of action of antidepressants in the four plates test

The results strongly suggest that activation of 5- HT2A receptors is critically involved in the anxiolytic activity of paroxetine, whereas the 5-HT2A and 5-ht2B receptors are involved inThe anti-punishment action of venlafaxine in the FPT.

Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression

The results indicate that the selective agonist (CP 94253) and antagonists (SB 216641 and GR 127935) of 5-HT1B receptors produce effects that are characteristic of anxiolytics, in the preclinical models used; however, CP 94253 also behaves like an antidepressant drug.

Lack of potentiation of the anti-alcohol effects of fluoxetine by pindolol in alcohol-preferring caa rats

Effect of noradrenergic system on the anxiolytic-like effect of DOI (5-HT2A/2C agonists) in the four-plate test

The results indicate that the DOI seems to act on the 5-HT2 receptors post-synaptically located, and the effect of DOI is regulated by the α2-adrenoceptors.



5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice.

From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the5-HT2-re receptor subtype is not involved in this effect.

Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.

The data indicate that MDL 100,907 has a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability.

Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

  • D. S. KreissI. Lucki
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1995
It is suggested that repeated treatment with antidepressant drugs alters extracellular levels of 5-HT and the ability of 4-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to decrease 5- HT release in both the striatum and hippocampus.

Effects of 5‐HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents

Generality suggests that elevated synaptic 5‐HT could be responsible for the effects of these latter agents and selective inhibition of marble burying was not found to be a property of 5‐ HT‐related putative and actual anxiolytic agents.

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

Preclinical data indicate that MDL 100,907 is a potent and selective ligand at the 5-HT2A receptor and selectivity as a potential antipsychotic in that it lacked consistent activity in selected rodent models of anticonvulsant, antidepressant, analgesic, or anxiolytic activity.

The effects of 5-HT receptor ligands on ultrasonic calling in mouse pups

(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists.

It is demonstrated that 5-HT2A receptors mediate HTW in rats and that both D1 and D2 receptors as well as (postsynaptic) 5- HT1A receptors play a role in their expression.