The role of 4'-phosphopantetheine in t' biosynthesis of fatty acids, polyketides and peptides.

@article{Kleinkauf2000TheRO,
  title={The role of 4'-phosphopantetheine in t' biosynthesis of fatty acids, polyketides and peptides.},
  author={Horst Kleinkauf},
  journal={BioFactors},
  year={2000},
  volume={11 1-2},
  pages={91-2}
}
The peptide part of CoA, 4'-phosphopantetheine, has been identified as an essential cofactor in in the biosynthesis of fatty acids, polyketides, depsipeptides, peptides, and compounds derived from both carboxylic and amino acid precursors, like rapamycin. The cofactor is attached to a unique protein moiety, referred to as acyl carrier protein, aminoacyl carrier protein, or peptidyl carrier protein. These carrier proteins are either associated to enzyme complexes (type II) or integrated within… CONTINUE READING

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