The role of 3‐dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine
@article{Foti2003TheRO, title={The role of 3‐dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine}, author={Caterina Foti and Domenico Bonamonte and Giuseppe Mascolo and Angela Corcelli and Simona Lobasso and Luigi Rigano and Gianni D. Angelini}, journal={Contact Dermatitis}, year={2003}, volume={48} }
Since it has been found that all subjects with contact allergy to cocamidopropylbetaine (CAPB) have positive reactions to 3‐dimethylaminopropylamine (DMAPA), and reports have appeared in literature of the sensitizing action of amidoamine in products containing CAPB, we aimed to verify the possibility that pure amidoamine may have a sensitizing role in subjects with positive reactions to CAPB. To this end, in 10 patients with contact allergy to a commercial CAPB, we tested DMAPA 1% aq. and a…
47 Citations
Cutaneous Delayed-Type Hypersensitivity to Surfactants
- MedicineDermatitis : contact, atopic, occupational, drug
- 2015
This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), OPD, and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactant.
Eyelid Dermatitis: Contact Allergy to 3‐(Dimethylamino)propylamine
- MedicineDermatitis : contact, atopic, occupational, drug
- 2008
A 42‐year‐old woman with intractable eyelid dermatitis is presented with sensitization to 3‐(dimethylamino)propylamine (DMAPA), an important etiology of allergic contact dermatitis of the eyelids and face but is easily missed even with expanded‐series patch testing.
Allergic contact dermatitis to cocamidopropyl betaine in Colombia.
- BiologyAllergologia et immunopathologia
- 2012
Allergenicity and Cross‐Reactivity of Coconut Oil Derivatives: A Double‐Blind Randomized Controlled Pilot Study
- MedicineDermatitis : contact, atopic, occupational, drug
- 2006
The results substantiate previous experience that doubtful and mild reactions to CAPB may represent irritant reactions as opposed to true allergic reactions and suggest that cross‐reactivity and allergenicity of surfactants derived from coconut oil is largely unknown.
Epidemiology and Co-Reactivity of Novel Surfactant Allergens: A Double-Blind Randomized Controlled Study
- ChemistryDermatitis : contact, atopic, occupational, drug
- 2016
Isostearamidopropyl morpholine lactate may be an important emerging allergen with sensitivity rates comparable with those of oleamido-dimethylamine and dimethylaminopropylamine, and co-reactivity among surfactants was frequent except for cocamide DEA.
Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to surfactants.
- MedicineJournal of the American Academy of Dermatology
- 2014
Allergic contact dermatitis to cocamidopropyl betaine in Colombia
- Medicine
- 2017
The second symposium on the definition and Management of anaphylaxis and the risk for Cardiopulmonary Adverse Events and Epidemiology of life-threatening and lethal anaphYLaxis: a review was held in Washington, DC.
Allergic contact dermatitis in children: common allergens and treatment: a review
- MedicineCurrent opinion in pediatrics
- 2009
The prevalence, diagnostic methods, frequent allergens and treatment options in pediatric ACD are addressed and the relevance of positive reactions are demonstrated and ACD as a disease entity in children is confirmed.
A novel GJB3 (Cx31) missense mutation in a Chinese patient with erythrokeratodermia variabilis
- MedicineJournal of the European Academy of Dermatology and Venereology : JEADV
- 2011
CAPB patch tests are not efficient enough to detect contact allergy to commercial CAPB, containing DMAPA as impurity, so cosmetics should be suspect even if they were used ‘safely’ for a long time, in case of a change in the supplier of ingredients.
References
SHOWING 1-10 OF 24 REFERENCES
3‐Dimethylaminopropylamine: a key substance in contact allergy to cocamidopropylbetaine?
- ChemistryContact dermatitis
- 1995
The results suggest that the DMPA present at various levels as an impurity in the commercial product is responsible for cocamidopropylbetaine allergy.
Clinical allergy to cocamidopropyl betaine: reactivity to cocamidopropylamine and lack of reactivity to 3‐dimethylaminopropylamine
- BiologyContact dermatitis
- 2001
Results suggest that DMAPA is unlikely to be an important contact allergen in CAPB of appropriate quality and confirm thatCAPB of suitable purity, where levels of both cocamidopropylamine andDMAPA are minimized, is likely to trigger reactions in those ostensibly allergic to the material.
Contact allergy to impurities in surfactants: amount, chemical structure and carrier effect in reactions to 3‐dimethylaminopropylamine
- ChemistryContact dermatitis
- 1996
The study showed that DMPA remains as a quantitatively detectable impurity in all tensioactives employing it in their synthesis, and that no sensitizing action can be attributed to the functional groups present in alkylamidopropylbetaine molecules.
Provocative use testing of methyldibromo glutaronitrile in a cosmetic shampoo
- MedicineContact dermatitis
- 2000
Evidence is provided to support that a shampoo product containing 0.02% MDGN may safely be used by most individuals who are presensitized to MDGN.
Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study
- MedicineContact dermatitis
- 1997
Most subjects who were patch‐test‐positive showed a reaction when using CAPB‐containing skin and hair care products, and the chemical amidoamine, which is a known contaminant of CAPB preparations, is likely to be the actual sensitizer in most cases rather than CAPB itself.
Allergy to cocamidopropyl betaine may be due to amidoamine : a patch test and product use test study
- Medicine
- 1997
Most subjects who were patch-test-positive showed a reaction when using CAPB-containing skin and hair care products, and the results do not rule out the possibility that CAPB itself may be an allergen in rare cases.
Carrier and inhibitory effects of surfactants on allergic contact reactions to 3‐dimethylaminopropylamine
- ChemistryContact dermatitis
- 1998
It has been demonstrated that the activity of DMPA in the elicitation of allergic reactions is generally increased by the surfactants in which it has been dissolved (carrier effect), and this relationship is explored further.
Aminoethylethanolamine: a new allergen in cosmetics?
- ChemistryContact dermatitis
- 2001
Combined eczematous reactions to AEE and sodium lauroamphoacetate can be consequent to the presence of the former substance as an impurity in amphoacetates‐containing products, as demonstrated by ion chromatography‐mass spectrometry analysis.
The allergen cocamidopropyl betaine
- MedicineContact dermatitis
- 1998
The authors’ overall assessment design was an involved procedure by elimination, which lasted over 6 weeks, required many successive challenges in the patients, and featured a progressive drop in the population such as to result in a statistically irrelevant final sample.
Pure cocamidopropylbetaine is not the allergen in patients with positive reactions to commercial cocamidopropylbetaine
- ChemistryContact dermatitis
- 1996
Allergic contact dermatitis from antimycotic imidazoles is uncommon when compared to their widespread use, and the high concentration of tioconazole, the presence of undecylenic acid and of ethyl acetate in the vehicle, as well as its application to periungual folds are all factors favouring sensitization.