The role of 3‐dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine

@article{Foti2003TheRO,
  title={The role of 3‐dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine},
  author={Caterina Foti and Domenico Bonamonte and Giuseppe Mascolo and Angela Corcelli and Simona Lobasso and Luigi Rigano and Gianni D. Angelini},
  journal={Contact Dermatitis},
  year={2003},
  volume={48}
}
Since it has been found that all subjects with contact allergy to cocamidopropylbetaine (CAPB) have positive reactions to 3‐dimethylaminopropylamine (DMAPA), and reports have appeared in literature of the sensitizing action of amidoamine in products containing CAPB, we aimed to verify the possibility that pure amidoamine may have a sensitizing role in subjects with positive reactions to CAPB. To this end, in 10 patients with contact allergy to a commercial CAPB, we tested DMAPA 1% aq. and a… 
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CAPB patch tests are not efficient enough to detect contact allergy to commercial CAPB, containing DMAPA as impurity, so cosmetics should be suspect even if they were used ‘safely’ for a long time, in case of a change in the supplier of ingredients.
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References

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TLDR
The results suggest that the DMPA present at various levels as an impurity in the commercial product is responsible for cocamidopropylbetaine allergy.
Clinical allergy to cocamidopropyl betaine: reactivity to cocamidopropylamine and lack of reactivity to 3‐dimethylaminopropylamine
TLDR
Results suggest that DMAPA is unlikely to be an important contact allergen in CAPB of appropriate quality and confirm thatCAPB of suitable purity, where levels of both cocamidopropylamine andDMAPA are minimized, is likely to trigger reactions in those ostensibly allergic to the material.
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TLDR
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Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study
TLDR
Most subjects who were patch‐test‐positive showed a reaction when using CAPB‐containing skin and hair care products, and the chemical amidoamine, which is a known contaminant of CAPB preparations, is likely to be the actual sensitizer in most cases rather than CAPB itself.
Allergy to cocamidopropyl betaine may be due to amidoamine : a patch test and product use test study
TLDR
Most subjects who were patch-test-positive showed a reaction when using CAPB-containing skin and hair care products, and the results do not rule out the possibility that CAPB itself may be an allergen in rare cases.
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TLDR
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TLDR
Allergic contact dermatitis from antimycotic imidazoles is uncommon when compared to their widespread use, and the high concentration of tioconazole, the presence of undecylenic acid and of ethyl acetate in the vehicle, as well as its application to periungual folds are all factors favouring sensitization.
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