The role of 2-keto-4-pentenoic acid in seizures induced by allylglycine.

@article{Horton1978TheRO,
  title={The role of 2-keto-4-pentenoic acid in seizures induced by allylglycine.},
  author={R. Horton},
  journal={Biochemical pharmacology},
  year={1978},
  volume={27 10},
  pages={
          1471-7
        }
}
  • R. Horton
  • Published 1978
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Abstract 2 Keto-4-pentenoic acid (2K4PA) was synthesised from l -allylglycine (L-AG) using purified l -amino acid oxidase and isolated relatively free from allylglycine (AG) contamination. 2 keto-4-pentenoic acid is a potent inhibitor of cerebral glutamic acid decarboxylase (GAD) activity, being one to two thousand times more effective than AG. Simultaneous addition of 2K4PA and substrate to GAD gave classical competitive inhibition plots, with a if K i of 10 −6 M. Preincubation of GAD with… CONTINUE READING
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    • R. Horton
    • Chemistry
    • Brain Research Bulletin
    • 1980
    • 33

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