The role of 17 beta-hydroxysteroid dehydrogenases
@article{Mindnich2004TheRO, title={The role of 17 beta-hydroxysteroid dehydrogenases}, author={R. Mindnich and G. Moeller and J. Adamski}, journal={Molecular and Cellular Endocrinology}, year={2004}, volume={218}, pages={7-20} }
The biological activity of steroid hormones is regulated at the pre-receptor level by several enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta -HSD). The latter are present in many microorganisms, invertebrates and vertebrates. Dysfunctions in human 17 beta-hydroxysteroid dehydrogenases result in disorders of biology of reproduction and neuronal diseases, the enzymes are also involved in the pathogenesis of various cancers. 17 beta-hydroxysteroid dehydrogenases reveal a… CONTINUE READING
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References
SHOWING 1-10 OF 181 REFERENCES
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
- Biology, Medicine
- Journal of molecular endocrinology
- 2000
- 289
- PDF
Structure and function of 17β-hydroxysteroid dehydrogenase type 1 and type 2
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 2001
- 53
Expression and regulation of 17 beta-hydroxysteroid dehydrogenase type 1.
- Chemistry, Medicine
- The Journal of endocrinology
- 1996
- 16
The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
- Biology
- The Journal of Steroid Biochemistry and Molecular Biology
- 1995
- 55
17β-hydroxysteroid dehydrogenase type 7 — an ancient 3-ketosteroid reductase of cholesterogenesis
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 2001
- 52
- PDF
11β-Hydroxysteroid dehydrogenase: unexpected connections
- Biology
- Trends in Endocrinology & Metabolism
- 2003
- 59
Evolution of 17β-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 2001
- 101
- PDF