The role of 17 beta-hydroxysteroid dehydrogenases

  title={The role of 17 beta-hydroxysteroid dehydrogenases},
  author={R. Mindnich and G. Moeller and J. Adamski},
  journal={Molecular and Cellular Endocrinology},
  • R. Mindnich, G. Moeller, J. Adamski
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The biological activity of steroid hormones is regulated at the pre-receptor level by several enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta -HSD). The latter are present in many microorganisms, invertebrates and vertebrates. Dysfunctions in human 17 beta-hydroxysteroid dehydrogenases result in disorders of biology of reproduction and neuronal diseases, the enzymes are also involved in the pathogenesis of various cancers. 17 beta-hydroxysteroid dehydrogenases reveal a… CONTINUE READING
    298 Citations
    Structure and function of human 17β-hydroxysteroid dehydrogenases
    • 124
    Multifunctionality of human 17β-hydroxysteroid dehydrogenases
    • 111
    SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation
    • 53
    Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design.
    • 38
    Perspectives in Understanding the Role of Human 17β‐Hydroxysteroid Dehydrogenases in Health and Disease
    • 35
    Structural basis of the multispecificity demonstrated by 17β-hydroxysteroid dehydrogenase types 1 and 5
    • 41


    A guide to 17β-hydroxysteroid dehydrogenases
    • 145
    Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
    • 289
    • PDF
    Structure and function of 17β-hydroxysteroid dehydrogenase type 1 and type 2
    • 53
    Expression and regulation of 17 beta-hydroxysteroid dehydrogenase type 1.
    • 16
    The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
    • 55
    11β-Hydroxysteroid dehydrogenase: unexpected connections
    • 59
    Evolution of 17β-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action
    • M. Baker
    • Biology, Medicine
    • Molecular and Cellular Endocrinology
    • 2001
    • 101
    • PDF