The role of 11β-hydroxysteroid dehydrogenases in the brain

@article{Holmes2006TheRO,
  title={The role of 11β-hydroxysteroid dehydrogenases in the brain},
  author={Megan Holmes and Jonathan R Seckl},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={248},
  pages={9-14}
}
Abstract Glucocorticoids have a plethora of effects within the body to maintain homeostasis. In the brain they modify learning, memory and fear behaviours as well as regulating their own secretion by a negative feedback action. 11β-Hydroxysteroid dehydrogenases (11β-HSDs) are glucocorticoid metabolising enzymes that modify actions of glucocorticoids in a tissue specific manner. 11β-HSD1 regenerates active glucocorticoids from their inactive 11-keto derivatives, hence boosting tissue levels of… CONTINUE READING

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