The role of β2-glycoprotein I (β2GPI) in the activation of plasminogen

  title={The role of β2-glycoprotein I (β2GPI) in the activation of plasminogen},
  author={Francisco L{\'o}pez-Lira and Luis Rosales-Le{\'o}n and Ver{\'o}nica Monroy Mart{\'i}nez and Blanca Hayd{\'e} Ruiz Ordaz},
Abstract β2-glycoprotein I (β2GPI) is a glycoprotein of unknown physiological function. It is the main target antigen for antiphospholipid antibodies in patients with antiphospholipid syndrome (APS). β2GPI binds with high affinity to the atherogenic lipoprotein Lp(a) which shares structural homology with plasminogen, a key molecule in the fibrinolytic system. Impaired fibrinolysis has been described in APS. The present work reports the interaction between β2GPI and Glu-Plasminogen which may… CONTINUE READING