The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat

@article{Kalkman1998TheRO,
  title={The role of $\alpha$2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat},
  author={Hans Otto Kalkman and V Neumann and D. Hoyer and Mark David Tricklebank},
  journal={British Journal of Pharmacology},
  year={1998},
  volume={124}
}
1 The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2 The close structural analogues of clozapine, loxapine (0.1 mg kg−1 s.c.) and iso‐clozapine (1 and 3 mg kg−1 s.c.) induced catalepsy in rats. In contrast, clozapine and the regio‐isomer of loxapine, iso‐loxapine (up to 10 mg kg−1 s.c.) did not produce catalepsy, but at a dose of 1 mg kg−1 significantly inhibited catalepsy induced by loxapine (0.3 mg kg−1 s.c… 
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