The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat

@article{Kalkman1998TheRO,
  title={The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat},
  author={H. Kalkman and V. Neumann and D. Hoyer and M. Tricklebank},
  journal={British Journal of Pharmacology},
  year={1998},
  volume={124}
}
1 The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2 The close structural analogues of clozapine, loxapine (0.1 mg kg−1 s.c.) and iso‐clozapine (1 and 3 mg kg−1 s.c.) induced catalepsy in rats. In contrast, clozapine and the regio‐isomer of loxapine, iso‐loxapine (up to 10 mg kg−1 s.c.) did not produce catalepsy, but at a dose of 1 mg kg−1 significantly inhibited catalepsy induced by loxapine (0.3 mg kg−1 s.c… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats
Combined antagonism of adrenoceptors and dopamine and 5-HT receptors underlies the atypical profile of clozapine.
5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential
Do central antiadrenergic actions contribute to the atypical properties of clozapine?
Putting the 'A' in atypical: does α2-adrenoceptor antagonism account for the therapeutic advantage of new antipsychotics?
  • D. Nutt
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 1994
Behavioural effects of serotonin agonists and antagonists in the rat and marmoset
Behavioral Effects of Clozapine and Dopamine Receptor Subtypes
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
  • L. Chiodo, B. Bunney
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1983
...
1
2
3
4
5
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