The role of α1L-adrenoceptor in rat urinary bladder: Comparison between young adult and aged rats

  title={The role of $\alpha$1L-adrenoceptor in rat urinary bladder: Comparison between young adult and aged rats},
  author={Yasunori Suzuki and Nobuo Moriyama and Atsunori Kanada and Y Okaya and Kazuki Kawabe and Kazuo Aisaka},
  journal={Life Sciences},

Selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder

The augmentation of α-adrenoceptor-mediated contractions in aged bladder may induce urinary dysfunction such as voiding difficulty, which may be related to inflammation and hypertrophy.

Increased α1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats

ObjectivesA possibility that aging affects (a) expression of the α1D-adrenergic receptor (AR1D), (b) AR1D-mediated contractions and (c) sympathetic innervation in the urinary bladder in rats was

Smooth muscle and parasympathetic nerve terminals in the rat urinary bladder have different subtypes of α1 adrenoceptors

It is concluded that α1A and CEC sensitive α1B and/or α1D adrenoceptors are expressed in the rat bladder in different locations and mediate smooth muscle contraction on the cholinergic nerve terminals.

Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals

The differential effects of aging on detrusor contraction are associated to alterations of [Ca2+]i signals: the cholinergic inhibition is due to inhibition of voltage-operated Ca2+ influx and reduction of the size of intracellular Ca2 + stores, while the age-induced ATP response is accompanied by an enhanced Ca2+, mobilization.



α1L‐Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man

The RBN appears to provide a predictive pharmacological assay for the study of NA‐induced smooth muscle contraction in LUT tissues of man.

Pharmacological subclassification of α1‐adrenoceptors in vascular smooth muscle

The results suggest that α1 ‐adrenoceptors of blood vessels can be divided into three subtypes (designated as α1H, α1L and α1N) by antagonist affinity and their susceptibility to chloroethylclonidine but not to nifedipine.

Evaluation of .ALPHA.1-Adrenoceptor Subtypes in Human Hypertrophied Prostate Using (3H)YM617, an .ALPHA.1-Selective Antagonist.

These experiments indicate that ca 70% of α1-adrenoceptor binding sites in the hypertrophied prostate are insensitive to C EC, while ca 30% of that are sensitive to CEC.


It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptor but both regions possess both types of adrenoceptor.

Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part II.

The results shown in the present paper indicate that the potencies of different alpha-1 antagonists against the contractions induced by norepinephrine on tissues of the lower urinary tract of rabbits and dogs are better correlated with their affinity for the putativealpha-1L subtype than for theAlpha-1a subtype.

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification.

Findings indicate that contractile responses to NE in human LUT tissues are mediated by a receptor displaying pharmacological properties that are clearly different from those of the defined alpha 1A-adrenoceptor and raise the possibility that multiple forms of the alpha 1a-adRenoceptor may exist inhuman LUT that are discriminated by RS-17053.