The role for endoplasmic reticulum stress in diabetes mellitus.

  title={The role for endoplasmic reticulum stress in diabetes mellitus.},
  author={Decio L. Eizirik and Alessandra K. Cardozo and Miriam Cnop},
  journal={Endocrine reviews},
  volume={29 1},
Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of diabetes, contributing to pancreatic beta-cell loss and insulin resistance. Components of the unfolded protein response (UPR) play a dual role in beta-cells, acting as beneficial regulators under physiological conditions or as triggers of beta-cell dysfunction and apoptosis under situations of chronic stress. Novel findings suggest that "what makes a beta-cell a beta-cell", i.e., its… CONTINUE READING
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