The road to linearity: why linearity at low doses became the basis for carcinogen risk assessment

  title={The road to linearity: why linearity at low doses became the basis for carcinogen risk assessment},
  author={Edward J. Calabrese},
  journal={Archives of Toxicology},
This article assesses the historical foundations of how linearity at low dose became accepted by the scientific/regulatory communities. While the threshold model was used in the 1920s/1930s in establishing radiation health standards, its foundations were challenged by the genetics community who argued that radiation induced mutations in reproductive cells followed a linear response, were cumulative and deleterious. Scientific foundations of linearity for gonadal mutations were based on non… CONTINUE READING
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