The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.

@article{Viktorin2014TheRO,
  title={The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.},
  author={Alexander Viktorin and Paul Lichtenstein and Michael E. Thase and Henrik Larsson and Cecilia Lundholm and Patrik K. E. Magnusson and Mikael Land{\'e}n},
  journal={The American journal of psychiatry},
  year={2014},
  volume={171 10},
  pages={
          1067-73
        }
}
OBJECTIVE This study examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated either with antidepressant monotherapy or with an antidepressant in conjunction with a mood stabilizer. METHOD Using Swedish national registries, the authors identified 3,240 patients with bipolar disorder who started treatment with an antidepressant and had no antidepressant treatment during the previous year. Patients were categorized into those receiving antidepressant… Expand
View on PubMed
doi.org
132 Citations
Highly Influential Citations
5
Background Citations
35
Methods Citations
6
Results Citations
3

132 Citations

Citation Type

Citation Type

Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital
TLDR
A large proportion of patients with BAD on antidepressants experience medication-induced manic or hypomanic switch, and there was no significant difference in the rate of MS in either those treated with adjunct antidepressants therapy with a mood stabiliser or an antipsychotic or those placed on a combination of antidepressants, antipsychotics and mood-stabilising agents. Expand
The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
TLDR
No evidence was found for a positive association between methylphenidate and treatment-emergent mania among patients with bipolar disorder who were concomitantly receiving a mood-stabilizing medication. Expand
Trends in the psychopharmacological treatment of bipolar disorder: a nationwide register-based study
TLDR
The results show an increase in the proportion of patients with bipolar disorder being treated with antidepressants in the period from 1997 to 2012, however, the extent of antidepressant monotherapy decreased during the same period. Expand
Efficacy and safety of antidepressant's use in the treatment of depressive episodes in bipolar disorder - review of research.
TLDR
The authors review the literature concerning efficacy and safety of use of antidepressants in the treatment of affective disorders and long-term impact on the course of the disease and decide whether antidepressant monotherapy is allowed in severe depression. Expand
Adjunctive antidepressants in bipolar depression: A cohort study of six- and twelve-months rehospitalization rates
TLDR
Adjunctive-AD therapy to MS/AAP at discharge from BD-I depressive episode hospitalization is associated with a lower rate of and a longer time to rehospitalization during a 1-year follow up period. Expand
Epidemiological studies of medication use and effectiveness in bipolar disorder
TLDR
Findings indicate that efforts to reduce treatment delay should especially target patients who are naïve to moodstabilizers and antipsychotics or diagnosed with BD during a brief hospitalization, and that combination therapies including lithium, valproate and quetiapine or olanzapine were associated with the lowest risks of treatment failure. Expand
Changes in mood stabilizer prescription patterns in bipolar disorder.
TLDR
Significant changes in the prescription of drugs in the treatment of bipolar disorder have occurred in recent years in Sweden, and lithium use decreased steadily during the study period, while the use of lamotrigine and quetiapine increased. Expand
Clinical characteristics of antidepressant use and related manic switch in bipolar disorder
TLDR
It is suggested that the risk of manic switch is especially prominent in the first months of AD use, and Antidepressants use in combining it with a mood stabilizers (MS) may not be adequate in preventing switches in shorter terms. Expand
Evaluating the efficacy and safety of antidepressants in patients with bipolar disorder
TLDR
The authors conclude that the real question is not whether ADs should or should not be used in bipolar depression, but which patients benefit from these drugs and which ones are impaired. Expand
Safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for relapse-prevention of bipolar II depression: A randomized, double-blind, parallel-group, prospective study.
TLDR
Results suggest that continuation venlafaxine monotherapy may provide similar prophylactic effectiveness relative to lithium, with no difference in treatment-emergent hypomanic episodes and without the need for frequent serum lithium level and metabolic monitoring. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Risk factors for antidepressant-related switch to mania.
TLDR
Bipolar patients with an earlier age at onset and an illness course characterized by lower rate of response to antidepressants and higher rate of switches into mania or hypomania were found to be the ones with higher switch risk. Expand
Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients.
TLDR
Treatment with mood stabilizers may be a potent strategy to reduce the risk of antidepressant-induced maniform switches in bipolar I depressed patients. Expand
Antidepressant-induced mania in bipolar patients: identification of risk factors.
TLDR
The frequency of mood switching associated with acute antidepressant therapy may be reduced by lithium treatment, and particular attention should be paid to patients with a hyperthymic temperament, who have a greater risk of mood switches. Expand
Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
TLDR
Antidepressants are associated with the potential risk for treatment-emergent mania or hypomania, particularly in bipolar patients with short illness duration, multiple past antidepressant trials, and past experience of switch with at least one antidepressant. Expand
Bipolar depression and antidepressant-induced mania: a naturalistic study.
TLDR
The frequency and severity of postdepressive mood elevation associated with acute or continuation antidepressant therapy may be reduced by mood stabilizers, which may be more likely in patients with a strong history of mania. Expand
Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
Objective: The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar… Expand
Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression.
TLDR
Both treatments appeared to be effective; however, the addition of an antidepressant may have greater clinical utility in the treatment of bipolar depression. Expand
Antidepressant-induced mania and cycle acceleration: a controversy revisited.
TLDR
Antidepressant-induced mania may be a marker for increased vulnerability to antidepressant-induced cycle acceleration and is associated with younger age at first treatment and may be more likely to occur in women and in bipolar II patients. Expand
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
TLDR
Continuing treatment with antidepressants in patients with depressive disorders who have responded to acute treatment reduced the odds of relapse by 70% and seemed to persist for up to 36 months, although most trials were of 12 months' duration, and so the evidence on longer-term treatment requires confirmation. Expand
Antidepressant-induced mania: an overview of current controversies.
TLDR
About one-quarter to one-third of bipolar patients may be inherently susceptible to antidepressant-induced manias, and bipolar patients with a strong genetic loading for bipolar illness whose initial illness begins in adolescence or young adulthood may be especially at risk. Expand
...
1
2
3
4
...