The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.

@article{Viktorin2014TheRO,
  title={The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.},
  author={Alexander Viktorin and Paul Lichtenstein and Michael E. Thase and Henrik Larsson and Cecilia Lundholm and Patrik K. E. Magnusson and Mikael Land{\'e}n},
  journal={The American journal of psychiatry},
  year={2014},
  volume={171 10},
  pages={
          1067-73
        }
}
OBJECTIVE This study examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated either with antidepressant monotherapy or with an antidepressant in conjunction with a mood stabilizer. METHOD Using Swedish national registries, the authors identified 3,240 patients with bipolar disorder who started treatment with an antidepressant and had no antidepressant treatment during the previous year. Patients were categorized into those receiving antidepressant… Expand
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138 Citations

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References

SHOWING 1-10 OF 35 REFERENCES
Risk factors for antidepressant-related switch to mania.
TLDR
Bipolar patients with an earlier age at onset and an illness course characterized by lower rate of response to antidepressants and higher rate of switches into mania or hypomania were found to be the ones with higher switch risk. Expand
Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients.
TLDR
Treatment with mood stabilizers may be a potent strategy to reduce the risk of antidepressant-induced maniform switches in bipolar I depressed patients. Expand
Antidepressant-induced mania in bipolar patients: identification of risk factors.
TLDR
The frequency of mood switching associated with acute antidepressant therapy may be reduced by lithium treatment, and particular attention should be paid to patients with a hyperthymic temperament, who have a greater risk of mood switches. Expand
Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
TLDR
Antidepressants are associated with the potential risk for treatment-emergent mania or hypomania, particularly in bipolar patients with short illness duration, multiple past antidepressant trials, and past experience of switch with at least one antidepressant. Expand
Bipolar depression and antidepressant-induced mania: a naturalistic study.
TLDR
The frequency and severity of postdepressive mood elevation associated with acute or continuation antidepressant therapy may be reduced by mood stabilizers, which may be more likely in patients with a strong history of mania. Expand
Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
Objective: The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar… Expand
Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression.
TLDR
Both treatments appeared to be effective; however, the addition of an antidepressant may have greater clinical utility in the treatment of bipolar depression. Expand
Antidepressant-induced mania and cycle acceleration: a controversy revisited.
TLDR
Antidepressant-induced mania may be a marker for increased vulnerability to antidepressant-induced cycle acceleration and is associated with younger age at first treatment and may be more likely to occur in women and in bipolar II patients. Expand
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
TLDR
Continuing treatment with antidepressants in patients with depressive disorders who have responded to acute treatment reduced the odds of relapse by 70% and seemed to persist for up to 36 months, although most trials were of 12 months' duration, and so the evidence on longer-term treatment requires confirmation. Expand
Antidepressant-induced mania: an overview of current controversies.
TLDR
About one-quarter to one-third of bipolar patients may be inherently susceptible to antidepressant-induced manias, and bipolar patients with a strong genetic loading for bipolar illness whose initial illness begins in adolescence or young adulthood may be especially at risk. Expand
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