The risk of occurrence of venous thrombosis: focus on protein Z.

  title={The risk of occurrence of venous thrombosis: focus on protein Z.},
  author={Valeria Bafunno and Rosa Santacroce and Maurizio Margaglione},
  journal={Thrombosis research},
  volume={128 6},
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 characterized by an homology with other vitamin K-dependent factors. PZ acts as the cofactor of the PZ dependent inhibitor (ZPI), in the inhibition of activated factor X bound on phospholipid surface. In humans, PZ is characterized by an unusual wide distribution in plasma partly explained by a genetic control. Several PZ gene polymorphisms influencing plasma concentration have been described. In mice, the… CONTINUE READING

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