The risk of fractures in postmenopausal women with primary hyperparathyroidism.

@article{DeGeronimo2006TheRO,
  title={The risk of fractures in postmenopausal women with primary hyperparathyroidism.},
  author={Simona De Geronimo and Elisabetta Romagnoli and Daniele Diacinti and E. D'erasmo and Salvatore Minisola},
  journal={European journal of endocrinology},
  year={2006},
  volume={155 3},
  pages={
          415-20
        }
}
OBJECTIVE To evaluate the prevalence of vertebral (vFr) and non-vertebral (nvFr) fractures in postmenopausal women with primary hyperparathyroidism (PHPT). MATERIALS AND METHODS We studied 98 patients with PHPT, divided into 'mild' (M, n = 25) and 'non-mild' (NM, n = 73) sub-groups, according to recently published guidelines (2002), and 89 healthy women (C) matched for age, years since menopause and body mass index. vFr was evaluated according to a visual semiquantitative method; bone mineral… 
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Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism.
TLDR
VF rate is increased in postmenopausal women with PHPT compared to controls, independently of whether they are classified as symptomatic or asymptomatic, and the question of whether the finding of mild morphometric VFs in the latter represents an indication for parathyroid surgery remains to be established.
Prevalence and Risk of Vertebral Fractures in Primary Hyperparathyroidism: A Nested Case‐Control Study
TLDR
The severity of PHPT assessed by biochemistry does not seem to be associated with risk of VFx, and VFX seems to occur at a higher BMD in PHPT.
Risk factors for vertebral fracture in primary hyperparathyroidism
TLDR
The data do not support limiting screening to PHPT patients with specific VF risk factors, which included older age, prior fracture, worse renal function and osteoporosis at the hip, but not osteopOrosis at other sites, TBS or biochemical indices of PHPT.
Prevalence of cortical osteoporosis in mild and severe primary hyperparathyroidism and its relationship with bone markers and vitamin D status.
  • F. Bandeira, L. Griz, +5 authors E. Diniz
  • Medicine
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • 2009
Factors associated with vertebral fracture risk in patients with primary hyperparathyroidism.
TLDR
In PHPT, VFx is associated positively with age, negatively with sCa and spinal BMD, and presence of at least one copy of the CASR A986S SNP.
Trabecular Bone Score (TBS) in Primary Hyperparathyroidism (PHPT): A Useful Tool?
Prevalence of kidney stones and vertebral fractures in primary hyperparathyroidism using imaging technology.
TLDR
Evidence is provided in support of recent recommendations that a more proactive approach be taken to detect silent bone and stone disease in asymptomatic PHPT.
Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism.
TLDR
In primary hyperparathyroidism (PHPT), bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery, and showed a better compromise between sensitivity and specificity for detecting VFX than LS-BMD, TH- BMD and FN-BMd.
The Risk of Fractures in Primary Hyperparathyroidism: A Meta‐Analysis
TLDR
It was found that patients with PHPT had a significantly increased risk of VF and TF in comparison with controls, and older age, longer duration since menopause, and lower BMD at lumbar spine and distal radius were predictors for VF.
Effects of parathyroidectomy versus observation on the development of vertebral fractures in mild primary hyperparathyroidism.
TLDR
Even though new vertebral fractures occurred only in the observation group, the frequency was not significantly different from the surgery group, and firm conclusions can be drawn about the long-term safety of observation, as opposed to surgery.
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