The risk of birth defects in children born after assisted reproductive technologies

@article{Kurinczuk2004TheRO,
  title={The risk of birth defects in children born after assisted reproductive technologies},
  author={Jennifer J. Kurinczuk and Michele Hansen and Carol Bower},
  journal={Current Opinion in Obstetrics and Gynecology},
  year={2004},
  volume={16},
  pages={201-209}
}
Purpose of review This review addresses the question of whether there is evidence of an increased risk of birth defects in children born following assisted reproductive technologies compared with spontaneously conceived children. Recent findings Three recent studies added relatively little new information given their modest size (56-472 assisted reproductive technology children). We therefore considered all published papers that compared birth defects in children born following assisted… 

Assisted reproductive technologies and the risk of birth defects--a systematic review.

TLDR
Pooled results from all suitable published studies suggest that children born following ART are at increased risk of birth defects compared with spontaneous conceptions.

Does assisted reproductive technology cause birth defects?

  • O. Bukulmez
  • Medicine
    Current opinion in obstetrics & gynecology
  • 2009
TLDR
All couples undergoing these procedures should be counseled about the current information suggesting elevated risks of birth defects, genetic abnormalities and imprinting disorders associated with infertility and the infertility treatment with ART.

Assisted reproductive technologies and birth outcomes: overview of recent systematic reviews.

TLDR
E Epidemiologists, in conjunction with clinical and laboratory colleagues, should now focus on large, methodologically sound studies with long-term follow up that seek to identify the reasons for increased risks and their long- term consequences, whether they are associated with particular technologies and causes of infertility, and how they might be reduced.

Reproductive technologies and the risk of birth defects.

TLDR
The increased risk of birth defects associated with IVF was no longer significant after adjustment for parental factors, and the risk of ICSI remained increased after multivariate adjustment, although the possibility of residual confounding cannot be excluded.

Comparison Between Children Born After Natural Conception and Those Born After Assisted Reproduction Technology: A Review of the Literature and Results from our Survey

TLDR
No increase in the malformation risk of infants born after ART treatment is defended, and whether this increased risk could be related to ART procedures or whether it is mainly related to parental characteristics is summarized.

Surveillance of congenital malformations in infants conceived through assisted reproductive technology or other fertility treatments.

TLDR
Ass assisted reproductive technology is associated with a slight excess risk of birth defects and the specific congenital malformations with elevated risks for singleton infants vary depending on the exposure.

Outcomes from assisted reproductive technology.

TLDR
Pregnancy rates after ART have shown nearly continuous improvement in the years since its inception, and because of its high pregnancy rate, couples are moving to ART more quickly in the management of their infertility.

Outcomes from assisted reproductive technology.

TLDR
Pregnancy rates after ART have shown nearly continuous improvement in the years since its inception, and because of its high pregnancy rate, couples are moving to ART more quickly in the management of their infertility.

Effect of parental physiological conditions and assisted reproductive technologies on the pregnancy and birth outcomes in infertile patients

TLDR
The data revealed that older parental age increases the risks of abortion, preterm birth and low body weight birth and suggested that both the parental physiological conditions and ART methods should be evaluated to develop better ART mediated infertility treatments.

Outcomes of IVF conceptions: are they different?

  • J. Halliday
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2007

References

SHOWING 1-10 OF 47 REFERENCES

The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization.

TLDR
Infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have twice as high a risk of a major birth defect as naturally conceived infants.

The effect of various infertility treatments on the risk of preterm birth.

TLDR
Comparison of singleton pregnancies following either low technology treatment or high technology treatment with that of naturally conceived pregnancies showed that younger and older age, previous perinatal death and emergency CS were associated with an increased risk, while a previous live birth reduced the risk.

Congenital malformations in 4224 children conceived after IVF.

TLDR
The small increase in overall congenital malformations observed in the IVF children appears to be attributable to differences in maternal characteristics and not to any aspect of theIVF procedure.

Neonatal outcome and congenital malformations in children born after in-vitro fertilization.

BACKGROUND To evaluate the neonatal outcome and the prevalence of congenital malformations in children born after IVF in northern Finland we carried out a population-based study with matched

Neonatal assessment of babies conceived by in vitro fertilization.

  • B. FischL. Harel P. Merlob
  • Medicine
    Journal of perinatology : official journal of the California Perinatal Association
  • 1997
TLDR
The overall neonatal morbidity in IVF babies was found to exceed that of the general population, although at birth, there were no clinical pathognomonic signs typical ofIVF babies, although more detailed metabolic, endocrine, and neurobehavioral studies are still required to confirm that newborns conceived in vitro do not differ from those conceived spontaneously in any of these respects.

Congenital malformations in infants born after IVF: a population-based study.

TLDR
It is postulated that the excessrisk for alimentary atresia, like the excess risk for monozygotic twinning after IVF, is a direct consequence of the IVF procedure and the extra risk for hypospadias after ICSI may be related to paternal subfertility with a genetic background.

Births in Great Britain resulting from assisted conception, 1978-87. MRC Working Party on Children Conceived by In Vitro Fertilisation.

TLDR
Multiple pregnancies often result from assisted conception and are the main determinant of the outcome of the pregnancies and of the health of the children at the time of birth.