The rise and fall of the chemoattractant receptor GPR33.

  title={The rise and fall of the chemoattractant receptor GPR33.},
  author={Holger R{\"o}mpler and Angela Schulz and Christian Pitra and Graham M Coop and Molly Przeworski and Svante P{\"a}{\"a}bo and Torsten Sch{\"o}neberg},
  journal={The Journal of biological chemistry},
  volume={280 35},
Chemokine and chemoattractant receptors are members of the large superfamily of G protein-coupled receptors (GPCR), which control leukocyte chemotaxis. In addition to their physiological role, several chemokine and chemoattractant receptors, such as CCR5 and Duffy, have been directly associated with pathogen entry. GPR33 is an orphan chemoattractant GPCR that was previously identified as a pseudogene in humans. GPR33 evolved in mammals about 125-190 million years ago. The cloning and analysis… CONTINUE READING