The rise and fall of insulin secretion in type 1 diabetes mellitus

@article{Tsai2005TheRA,
  title={The rise and fall of insulin secretion in type 1 diabetes mellitus},
  author={Emily B. Tsai and Nicole A. Sherry and Jerry P. Palmer and Kevan C Herold},
  journal={Diabetologia},
  year={2005},
  volume={49},
  pages={261-270}
}
An understanding of the natural history of beta cell responses is an essential prerequisite for interventional studies designed to prevent or treat type 1 diabetes. Here we review published data on changes in insulin responses in humans with type 1 diabetes. We also describe a new analysis of C-peptide responses in subjects who are at risk of type 1 diabetes and enrolled in the Diabetes Prevention Trial-1 (DPT-1). C-peptide responses to a mixed meal increase during childhood and through… CONTINUE READING