The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight

@article{King2006TheRF,
  title={The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight},
  author={Bruce M. King},
  journal={Physiology \& Behavior},
  year={2006},
  volume={87},
  pages={221-244}
}
  • B. M. King
  • Published 28 February 2006
  • Biology, Psychology
  • Physiology & Behavior
Comparison of the effect of lesions of ventromedial hypothalamus and posterodorsal amygdala on body weight and immunological parameters in albino Wistar rats
TLDR
The findings suggest that the role of VMH on feeding is more pronounced than PDA, indicating that VMH has a stronger regulation of adiposity than PPA, and though VMH and PDA are involved in the regulation of immune functions, VMH have a stronger control over immune functions than P DA.
Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus.
  • B. M. King
  • Biology, Psychology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2006
TLDR
The PDA is also a critical site for some aspects of rodent sexual behavior, particularly those that depend on olfaction, and the pattern of degeneration observed after obesity-inducing PDA lesions is remarkably parallel to the circuit that has been proposed to mediate sexual behavior.
Effect of Procainization of Ventromedial Nucleus of Hypothalamus on the Feeding Behavior of Rats
TLDR
The results suggest that bilateral procainization of VMH produces a transient increase in food intake and enhance preference for sweet tasting substances.
Role of ventromedial hypothalamus on energy homeostasis in albino rats: effect of gender.
TLDR
Following VMH lesion, male rats exhibited significant weight gain in the absence of proportionate hyperphagia indicating that weight-gain was mainly metabolic in nature, and the male rats developed more susceptibility to insulin resistance.
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation
TLDR
The results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher‐order learning and memory processes that contribute to the control of appetitive and consummatory behavior.
Increased noradrenergic activity in the ventromedial hypothalamus during treadmill running in rats.
TLDR
The results suggest that the increase in noradrenergic activity in the VMH is related to the enhancement of fat oxidation during exercise.
Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus
Steroidogenic factor 1 expressing neurons in the ventromedial hypothalamus regulate feeding, metabolism and risk-associated decision making
TLDR
It is concluded that SF1 neurons have complex functions in integrating internal energy state with risk decision making, appropriate metabolic regulation and feeding behaviour, and at least partially due to intrinsic synaptic properties of theSF1 neurons.
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References

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A re-examination of the ventromedial hypothalamic paradox
  • B. M. King
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1980
Comparison of ventromedial and paraventricular lesions in rats that become obese.
TLDR
The characteristics of obesity produced by PVN lesions differ from those resulting from VMH damage, and after pair feeding there was less distortion of the diurnal rhythm.
Dissociative analysis of ventromedial hypothalamic obesity syndrome.
TLDR
Electrolytic lesions of the ventromedial hypothalamus produce an obesity syndrome characterized by hyperphagia, adiposity, and heightened parasympathetic tone, and experiments demonstrate dissociations between hyperph Pagia and obesity, as well as between stomach secretion and Obesity in the VMH syndrome.
Ventromedial hypothalamic obesity: A reexamination of the irritative hypothesis
  • B. M. King
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1991
Dynamic and static phases of obesity following lesions in PVN and VMH.
TLDR
Data are consistent with the hypothesis that animals with PVN lesions do not show the disturbances in food intake or in the autonomic nervous system that characterize the VMH-lesioned rats.
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