The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

Abstract

Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.

DOI: 10.1039/c6mb00081a

5 Figures and Tables

Cite this paper

@article{Hegemann2016TheRR, title={The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.}, author={Julian D. Hegemann and Christopher D. Fage and Shaozhou Zhu and Klaus Harms and Francesco Saverio di Leva and Ettore Novellino and Luciana Marinelli and Mohamed A. Marahiel}, journal={Molecular bioSystems}, year={2016}, volume={12 4}, pages={1106-9} }