The riddle of formycin A insulinotropic action.

  title={The riddle of formycin A insulinotropic action.},
  author={Willy J Malaisse and Philippe Lebrun and Bernard Pirotte and Paul D. van Poelje and Concepci{\'o}n Vi{\~n}ambres and Mar{\'i}a Luisa Villanueva-Pe{\~n}acarrillo and Isabel Valverde and J G{\"a}bel and Patrik Rorsman},
  journal={Biochemical and molecular medicine},
  volume={57 1},
Formycin A augments insulin release evoked by glucose (5.6 mm or more), this effect not being rapidly reversible. The mechanism responsible for the insulinotropic action of formycin A was investigated in isolated pancreatic islets. It could not be ascribed to facilitation of glucose metabolism. On the contrary, formycin A inhibited glucose oxidation, lowered ATP content, and impaired glucose-stimulated protein biosynthesis. The insulinotropic action of formycin A was apparently attributable to… Expand
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