The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain.

@article{Helgstrand2007TheRS,
  title={The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain.},
  author={Magnus Helgstrand and Chandra Sekhar Mandava and Frans A. A. Mulder and Anders Liljas and Suparna Sanyal and Mikael Akke},
  journal={Journal of molecular biology},
  year={2007},
  volume={365 2},
  pages={468-79}
}
Efficient protein synthesis in bacteria requires initiation factor 2 (IF2), elongation factors Tu (EF-Tu) and G (EF-G), and release factor 3 (RF3), each of which catalyzes a major step of translation in a GTP-dependent fashion. Previous reports have suggested that recruitment of factors to the ribosome and subsequent GTP hydrolysis involve the dimeric protein L12, which forms a flexible "stalk" on the ribosome. Using heteronuclear NMR spectroscopy we demonstrate that L12 binds directly to the… CONTINUE READING
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