The ribosomal protein genes and Minute loci of Drosophila melanogaster

  title={The ribosomal protein genes and Minute loci of Drosophila melanogaster},
  author={Steven J. Marygold and John Roote and G{\"u}nter Reuter and Andrew G. Lambertsson and Michael Ashburner and Gillian H. Millburn and Paul M. Harrison and Zhan Yu and Naoya Kenmochi and Thomas C Kaufman and Sally J. Leevers and Kevin R Cook},
  journal={Genome Biology},
  pages={R216 - R216}
Mutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster, disruption of RP genes can result in the 'Minute' syndrome of dominant, haploinsufficient phenotypes, which include prolonged development, short and thin bristles, and poor fertility and viability. While more than 50 Minute loci have been defined genetically, only 15 have so far been characterized molecularly and… CONTINUE READING