The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

@inproceedings{Jannot2011TheRP,
  title={The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans},
  author={Guillaume Jannot and Sarah Bajan and Nellie J. Gigu{\`e}re and Samir Bouasker and Isabelle H. Banville and Sandra Piquet and Gyorgy Hutvagner and Martin J Simard},
  booktitle={EMBO reports},
  year={2011}
}
Despite the importance of microRNAs (miRNAs) in gene regulation, it is unclear how the miRNA-Argonaute complex--or miRNA-induced silencing complex (miRISC)--can regulate the translation of their targets in such diverse ways. We demonstrate here a direct interaction between the miRISC and the ribosome by showing that a constituent of the eukaryotic 40S subunit, receptor for activated C-kinase (RACK1), is important for miRNA-mediated gene regulation in animals. In vivo studies demonstrate that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

The genetics of Caenorhabditis elegans

  • S Brenner
  • Genetics
  • 1974
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…