The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

@inproceedings{Kampen2018TheRR,
  title={The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2
translation in T-ALL},
  author={Kim R Kampen and Sergey O. Sulima and Benno Verbelen and Tiziana Girardi and Stijn Vereecke and Gianmarco Rinaldi and Jelle Verbeeck and Joyce Op de Beeck and Anne Uyttebroeck and Jules P P Meijerink and Anthony V Moorman and Christine J Harrison and Pieter Spincemaille and Jan Cools and David M Cassiman and Sarah-Maria Fendt and Pieter Vermeersch and Kim De Keersmaecker},
  booktitle={Leukemia},
  year={2018}
}
The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described to impair cellular proliferation. The current study reveals that RPL10 R98S cells accumulate reactive oxygen species which promotes mitochondrial dysfunction and reduced ATP levels, causing the proliferation defect. RPL10 R98S mutant leukemia cells can survive high oxidative stress levels via a specific increase of IRES-mediated… CONTINUE READING
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